Endothelial cell–cell adhesion during zebrafish vascular development

Vascular Endothelial-Junctional Adhesion

Characterization of vascular mural cells during zebrafish development

Development and maturation of the nascent cardiovascular system requires the recruitment of mural cells (MCs) around the vascular tree in a process called vascular myogenesis. Understanding the origin and development of vascular MCs has been hampered by difficulties in observing these cells in vivo and performing defined genetic and experimental manipulations in available model organisms. Here,...

Effect of Vascular Cadherin Knockdown on Zebrafish Vasculature during Development

BACKGROUND Vascular endothelial cadherin (VE-cad) is essential for endothelial barrier integrity and vascular sprouting. However, the role of this important protein in cardiovascular development is only recently becoming apparent. METHODOLOGY/PRINCIPAL FINDINGS To characterize the role of VE-cadherin in cardiovascular development, we analyzed cardiovascular development in a zebrafish VE-cad k...

Ftr82 Is Critical for Vascular Patterning during Zebrafish Development

Cellular components and signaling pathways are required for the proper growth of blood vessels. Here, we report for the first time that a teleost-specific gene ftr82 (finTRIM family, member 82) plays a critical role in vasculature during zebrafish development. To date, there has been no description of tripartite motif proteins (TRIM) in vascular development, and the role of ftr82 is unknown. In...

Vascular endothelial adhesion molecules and tissue inflammation.